1. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  2. JAK
  3. JAK2 JH2 Tracer

JAK2 JH2 Tracer (Tracer 5) 是 JAK2 JH2 结构域的荧光探针,Kd 值为 0.2 μM。

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JAK2 JH2 Tracer Chemical Structure

JAK2 JH2 Tracer Chemical Structure

CAS No. : 2101955-00-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥4950
In-stock
1 mg ¥1500
In-stock
5 mg ¥4500
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

查看 JAK 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2].

体外研究
(In Vitro)

JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1].
JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM[1].
JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2].
Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

747.73

Formula

C38H27F2N7O6S

CAS 号
性状

固体

颜色

Light brown to brown

Emission (Em)

515

Excitation (Ex)

488

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : ≥ 83.3 mg/mL (111.40 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3374 mL 6.6869 mL 13.3738 mL
5 mM 0.2675 mL 1.3374 mL 2.6748 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3374 mL 6.6869 mL 13.3738 mL 33.4345 mL
5 mM 0.2675 mL 1.3374 mL 2.6748 mL 6.6869 mL
10 mM 0.1337 mL 0.6687 mL 1.3374 mL 3.3435 mL
15 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2290 mL
20 mM 0.0669 mL 0.3343 mL 0.6687 mL 1.6717 mL
25 mM 0.0535 mL 0.2675 mL 0.5350 mL 1.3374 mL
30 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1145 mL
40 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8359 mL
50 mM 0.0267 mL 0.1337 mL 0.2675 mL 0.6687 mL
60 mM 0.0223 mL 0.1114 mL 0.2229 mL 0.5572 mL
80 mM 0.0167 mL 0.0836 mL 0.1672 mL 0.4179 mL
100 mM 0.0134 mL 0.0669 mL 0.1337 mL 0.3343 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
JAK2 JH2 Tracer
目录号:
HY-102055
需求量: